Course

Bioinformatics Capstone: Big Data in Biology

University of California San Diego

Explore the intersection of big data and biology in the Bioinformatics Capstone: Big Data in Biology course offered by the University of California San Diego. Learn to leverage the BaseSpace cloud platform developed by Illumina to apply bioinformatics software approaches to real biological data. The course features a series of Application Challenges where you'll delve into genome assembly to track the source of a food poisoning outbreak, analyze gene expression data using RNA-Sequencing, and compare whole genome vs. whole exome sequencing for identifying harmful mutations in human samples. If you're up for a challenge, the hacker track offers the option to build a genome assembler and apply it to real data. This hands-on learning experience provides practical insights into bioinformatics, equipping you with the skills to tackle real-world biological data analysis scenarios.

  • Learn to use the BaseSpace cloud platform for bioinformatics analysis
  • Apply genome assembly to track the source of a food poisoning outbreak
  • Analyze gene expression data using RNA-Sequencing
  • Compare whole genome vs. whole exome sequencing for identifying harmful mutations in human samples
  • Hands-on hacker track option to build a genome assembler

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Bioinformatics Capstone: Big Data in Biology
Course Modules

Explore the course modules that cover the assembly and annotation of the SARS-CoV-2 genome, variant detection and classification of SARS-CoV-2, and the analysis of the SARS-CoV-2 spike protein structure.

Assembly and Annotation of the SARS-CoV-2 Genome

Delve into the assembly and annotation of the SARS-CoV-2 genome, gaining insight into the genetic makeup of the virus responsible for the COVID-19 pandemic. Explore the intricacies of genomic analysis and its applications in understanding the viral genome's structure and function.

Variant Detection and Classification of SARS-CoV-2

Dive into variant detection and classification of SARS-CoV-2, examining the genetic mutations and variations within the virus. Gain practical experience in identifying and categorizing different variants, essential for understanding the evolution and spread of the virus.

SARS-CoV-2 Spike Protein Structure Analysis

Analyze the SARS-CoV-2 spike protein structure, exploring the molecular architecture of this crucial viral component. Gain insights into the protein's structure and its implications in viral attachment and entry, offering valuable perspectives for understanding viral behavior and potential therapeutic targets.

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