Welcome to the Evidence-based Toxicology (EBT) course offered by Johns Hopkins University. This course delves into the revolutionary integration of evidence-based medicine principles into toxicology. Through a comprehensive exploration, participants will gain insights into systematic review, risk assessment, and quality assurance, all aimed at enhancing safety evaluations for humans and the environment.
The course is designed to showcase emerging efforts and address opportunities and challenges in the expanded use of evidence-based tools within toxicology, offering a comprehensive foundation for professionals and students alike.
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The course modules cover the shortcomings of current approaches, the history and causation in toxicology, systematic review and meta-analysis, risk of bias applications, quality assurance and validation, biometrical tools, and a summative assessment.
Welcome to the Introduction & Shortcomings of Current Approaches module. This section highlights the limitations of current toxicology approaches, including narrative reviews, bias, evidence writing, and inadequate reporting. Participants will gain insights into the impact of these shortcomings and their implications for the field of toxicology.
Module 2, History and Causation, delves into the historical development and principles of evidence-based toxicology. Participants will explore the Hill Principles of Epidemiology, the problem of causation in toxicology, and the concept of biomarkers in mechanistic toxicology. The module also addresses the future of causation in complex systems and the importance of evidence-based toxicology.
The Systematic Review and Meta-Analysis module provide a comprehensive understanding of the principles and protocols of systematic review and meta-analysis within the context of toxicology. Participants will learn to develop systematic review protocols, understand the history of meta-analysis, and engage in a mid-course exam to assess their knowledge.
Module 4, Risk of Bias & Application to Test Methods Comparison, explores the concept of risk of bias in critical appraisal, including examples from Cochrane Collaboration, SYRCLE's RoB Tool, and the National Institute for Environmental Health Sciences. Participants will understand the importance of risk assessment in evidence-based toxicology.
The Quality Assurance, Good Practices, and Validation module highlight the concepts of quality assurance and good practices in evidence-based toxicology. Participants will gain insights into the evolution of validation of alternative methods, the traditional validation process, and the importance of validation in the context of evidence-based toxicology.
Welcome to the Biometrical Tools & Future Perspectives module. This section emphasizes the need for biometry/statistics in evidence-based toxicology and their application in rigorous scientific approaches. Participants will explore the impact of risk and bias on evidence-based approaches and consider the future of evidence-based toxicology.
The Summative Assessment - Systematic Review Assignment module provides participants with an opportunity to synthesize and apply the knowledge gained throughout the course. Participants will engage in a comprehensive systematic review assignment, demonstrating their understanding and proficiency in evidence-based toxicology principles.
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