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Course

Introduction to Biomaterials

Indian Institute of Technology Kanpur

Introduction to basic concepts of Materials Science; Salient properties of important material classes; Property requirement of biomaterials; Concept of biocompatibility; Structure and properties of biological cells & tissues; cell-material interactions and foreign body response; Assessment of biocompatibility of biomaterials, in vitro biochemical assays (cellular adhesion, cellular viability using MTT, osteogenic differentiation using ALP assay; Biomnuneralisation using Osteocalcin assay);

In vivo testing and histocompatibility assessment; genotoxicity assessment (Physical damage to DNA by biomaterial eluates); important biometallic alloys: Ti-based, stainless steels, Co-Cr-Mo alloys; Bioinert, Bioactive and bioresorbable ceramics; Processing and properties of different bioceramic materials with emphasize on hydroxyapatite; synthesis of biocompatible coatings on structural implant materials; plasma spraying of carbon nanotube reinforced hydroxyapatite on Ti-6Al-4V substrate; Microstructure and properties of glass-ceramics; biodegradable polymers; Design concept of developing new materials for bio-implant applications.

Course topics:

  1. Introduction to basic concepts of Materials Science; Salient properties of important material classes
  2. Property requirement of biomaterials; Concept of biocompatibility
  3. Structure and properties of biological cells & tissues
  4. Cell-material interactions and foreign body response
  5. Assessment of biocompatibility of biomaterials
  6. In vitro biochemical assays (cellular adhesion, cellular viability using MTT, osteogenic differentiation using ALP assay; Biomnuneralisation using Osteocalcin assay)
  7. In vivo testing and histocompatibility assessment
  8. Genotoxicity assessment (Physical damage to DNA by biomaterial eluates)
  9. Important biometallic alloys: Ti-based, stainless steels, Co-Cr-Mo alloys
  10. Bioinert, Bioactive and bioresorbable ceramics
  11. Processing and properties of different bioceramic materials with emphasize on hydroxyapatite
  12. Synthesis of biocompatible coatings on structural implant materials
  13. Plasma spraying of carbon nanotube reinforced hydroxyapatite on Ti-6Al-4V substrate; in-vitro cytocompatibility
  14. Microstructure and properties of glass-ceramics
  15. Biodegradable polymers
  16. Design concept of developing new materials for bio-implant applications
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