Introduction to basic concepts of Materials Science; Salient properties of important material classes; Property requirement of biomaterials; Concept of biocompatibility; Structure and properties of biological cells & tissues; cell-material interactions and foreign body response; Assessment of biocompatibility of biomaterials, in vitro biochemical assays (cellular adhesion, cellular viability using MTT, osteogenic differentiation using ALP assay; Biomnuneralisation using Osteocalcin assay);
In vivo testing and histocompatibility assessment; genotoxicity assessment (Physical damage to DNA by biomaterial eluates); important biometallic alloys: Ti-based, stainless steels, Co-Cr-Mo alloys; Bioinert, Bioactive and bioresorbable ceramics; Processing and properties of different bioceramic materials with emphasize on hydroxyapatite; synthesis of biocompatible coatings on structural implant materials; plasma spraying of carbon nanotube reinforced hydroxyapatite on Ti-6Al-4V substrate; Microstructure and properties of glass-ceramics; biodegradable polymers; Design concept of developing new materials for bio-implant applications.
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